All About AMPK Activators
AMPK is the regulator that is maintaining cellular energy homeostasis which is basically the foundation of the body’s functionality. In mammals, AMPK regulates the energy balance both on whole body level via response to the hormones and the brain and on cellular levels by way of sensing ATP/AMP and ATP/ADP ratio levels.
ATP is actually the most significant energy molecule present in the body. Simply put, this is where cellular function all begins. Now because of the reason that energy is used by cells, ATP breaks down into ADP that actually has got less potential for energy. Then after, ADP breaks down to AMP that has got the least energy potential among all 3. As a matter of fact, this is where AMPK becomes crucial by sensing if there is appropriate ratio among ATP/ADP/AMP and from there, tells the body if it requires more ADP to function properly.
AMPK work on different processes via different mechanisms. Since the AMPK is considered as the master regulator for all functioning cells, it just makes sense. The effect that AMPK activation in the body depend on the complicated balance of factors and the signaling pathways. Still, there are many different benefits of having increased AMPK and these are:
Anti aging – as we begin to age, AMPK activation begins to decline. Some experts think that AMPK is among the contributing factors for aging. This promotes cellular renewal and at the same time, production of new mitochondria.
Anti inflammation – interestingly enough, AMPK activation can help in decreasing inflammation but it can be decreased as well by inflammation.
Anti diabetic – the truth is, AMPK is becoming more and more understood when it comes to its role in diabetes treatment mainly because of the ability it has in enhancing insulin sensitivity.
There are so many herbal products/constituents as well as nutritional products that have been proven to be an effective AMPK activator and some of it include:
Number 1. AICAR – in AMP, AICAR is considered as its analog that is necessary for cellular use and storage similar to ATP. AICAR has been studied and discovered to directly affect AMPKs activity that helps it to improve muscle performance all because it’s the analog of AMP.
Number 2. ALA – this is an abbreviation for Alpha Lipoic Acid that is a powerful AMPK activator and at the same time, popular for its effective antioxidant content. It’s been shown to boost the sensitivity of insulin in the body and also, carries anti obesity effects.
Number 3. Green tea extract – this was actually discovered to help in activating AMPK by means of activating its upstream kinase.
Number 4. Berberine – not just that it is an AMPK activator, it has berberine containing metformin which is great for anti-diabetes.